Effects of the compound extract of Chinese medicine on free radical metabolism of the rat brain in different states / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 160-164, 2012.
Article
em Zh
| WPRIM
| ID: wpr-329919
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of the "compound extract of Chinese medicine" on free radical metabolism and antioxidant enzyme systems of the rat brain.</p><p><b>METHODS</b>70 Wistar mice were randomly divided into two groups (n = 35): normal control group (N), taking medicine group (M). After a week of feeding, M group was taking medicine for 8 weeks. After 9 weeks, killed the two groups when they were at the rest state, the immediate ends of the fixed load, the immediate ends of exhaustive exercise and 12, 24 hour ends of exhaustive exercise, respectively. And the activity of malonaldehyde (MDA), glutathione peroxidase (GSH-PX), glutathione (GSH), superoxide dismutase (SOD), total anti oxidation capacity (T-AOC) of the rat brain were measured.</p><p><b>RESULTS</b>At the five states, the content of MDA in M group was lower than that in N group in different degree, the activity of GSH-PX, GSH, SOD, T-AOC in M group were higher than those in N group in different degree.</p><p><b>CONCLUSION</b>The "Compound extract of Chinese medicine" can reduce the MDA level of the rat brain and improve the enzyme activity of GSH-PX, GSH, SOD, T-AOC.</p>
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Índice:
WPRIM
Assunto principal:
Farmacologia
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Encéfalo
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Medicamentos de Ervas Chinesas
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Ratos Wistar
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Radicais Livres
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Metabolismo
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Antioxidantes
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2012
Tipo de documento:
Article