Effect of anti-human VEGF monoclonal antibody on VEGF level in serum of nude mice transplanted buccal carcinoma: a quantitative study / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 320-322, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-330055
ABSTRACT
<p><b>OBJECTIVE</b>Quantitative study of the effect of anti-human VEGF mAb E11 to VEGF level in serum of nude mice transplanted buccal carcinoma.</p><p><b>METHODS</b>E11 was administered into BALB/c nu/nu mice which were transplanted human buccal carcinoma. The saline was administrated as negative control. Mice were killed at 18 days. The VEGF level in serum of mice was determined by improved indirect ELISA.</p><p><b>RESULTS</b>Compared with the VEGF level in serum of mice in saline group, it was dramatically decreased in E11 group. The VEGF level in serum of mice treated E11 by subcutaneous was lowest and only reached (1.17 +/- 0.13) microg/L.</p><p><b>CONCLUSION</b>It demonstrated that the anti-human VEGF mAb could reduce the VEGF level in serum by binding VEGF, and block its biological activity. It indicates that VEGF in serum of malignant tumor patient is a new tumor marker.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Sangue
/
Carcinoma
/
Biomarcadores Tumorais
/
Fator A de Crescimento do Endotélio Vascular
/
Camundongos Endogâmicos BALB C
/
Camundongos Nus
/
Anticorpos Monoclonais
/
Mucosa Bucal
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2004
Tipo de documento:
Artigo
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