Heat injury induced apoptosis in rat striatum neurons / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To investigate the effect of hyperthermia on apoptosis of cultivated striatum neurons in the rat.</p><p><b>METHODS</b>After 30 min hyperthermia in 43 degrees, the Ca2+ concentration, the mitochondria membrane potential of the neuron were detected by Laser Scanning Confocal Microscopy (LSCM). The apoptosis of striatum neurons was detected by TUNEL staining.</p><p><b>RESULTS</b>Heat stress at 43 degrees C for 40 min caused an increase in the Ca2+ concentration of striatum neurons and a decrease in the mitochondria membrane potential of the striatum neurons.</p><p><b>CONCLUSION</b>The striatum shows more apoptosis neurons after heat stress.</p>