Advance in studies on natural antidepressant drugs and cytochrome P450 / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 828-832, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-330225
ABSTRACT
In the fast pace of modern life and under the heavy work pressure, the prevalence of depression has increased year by year. Meanwhile, the demands for antidepressant drugs have also grown, especially the high-efficiency and low-toxicity natural antidepressant drugs, mainly including polyphenols, flavonoids, organic acids, alkaloids and terpenoids. Cytochrome P450 (CYP450) is a type of enzymes involving oxidative metabolism of drugs in vivo, and can change the pharmacokinetics and efficacy of drugs. Therefore, it is of important significant to define the effect of natural antidepressant drugs on CYP450 in human bodies, in order to improve the rational clinical medication, avoid drug interactions and reduce adverse reactions.
Texto completo:
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Índice:
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Assunto principal:
Farmacologia
/
Medicamentos de Ervas Chinesas
/
Sistema Enzimático do Citocromo P-450
/
Depressão
/
Tratamento Farmacológico
/
Inibidores das Enzimas do Citocromo P-450
/
Metabolismo
/
Antidepressivos
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Artigo
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