A new flavonone from seeds of Alpinia katsumadai and its neuroprotective effect on PC12 cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2674-2678, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-330272
ABSTRACT
A new flavonone, named as (2R, 3S)-pinobanksin-3-cinnamate(1), together with six known compounds, pinocem-brin (2), pinobanksin (3), 3-O-acetylpinobanksin (4), galangin (5), kumatakenin(6), and 3-methylkaempferol (7), were isolated from a 95% ethanol extract of seeds of Alpinia katsumadai through a combination of various chromatographic techniques, including silica gel and Sephadex LH-20. The structure of compound 1 was elucidated by spectroscopic data analysis. Compound 1 exhibits a potent neuroprotective effect against the corticosterone-damaged PC12 cells, which may be underlying the effect by scavenging intracellular ROS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Sementes
/
Química
/
Colestenonas
/
Cinamatos
/
Células PC12
/
Morte Celular
/
Espécies Reativas de Oxigênio
/
Estresse Oxidativo
/
Fármacos Neuroprotetores
Limite:
Animais
Idioma:
Inglês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2014
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS