Correlation of ornidazole concentration in saliva and serum of healthy volunteers / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2108-2110, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-330770
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of ornidazole in the salivary and serum of healthy adults and explore the feasibility of monitoring serum drug concentration with salivary.</p><p><b>METHODS</b>Six volunteers received a single dose of 0.6 g ornidazole via intravenous infusion. The concentrations of ornidazole in the saliva and serum were assayed by high-performance liquid chomatography, and the correlation of the drug concentrations in saliva to that in serum was analyzed.</p><p><b>RESULTS</b>The concentration of ornidazole in the saliva was strongly associated with that in the serum (r = 0.825-0.969), and the ratio of saliva-to-serum concentration (S/P) of ornidazole was 0.99 ± 0.13.</p><p><b>CONCLUSION</b>Detection of saliva ornidazole concentration is feasible for monitoring the therapeutic concentration of ornidazole.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ornidazol
/
Saliva
/
Sangue
/
Farmacocinética
/
Estudos de Viabilidade
/
Cromatografia Líquida de Alta Pressão
/
Metabolismo
/
Antibacterianos
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
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