Correlation of CKP and VEGF expression and microvessel density to spiral CT manifestations of thymoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1896-1899, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-330811
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation of cytokeratin pan (CKP), vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) to spiral CT manifestations of thymoma.</p><p><b>METHODS</b>Eighty-four thymoma patients were underwent spiral CT examination, and 40 of the patients also had enhanced CT examination. All the CT findings were carefully reviewed to analyze their correlation to the expressions of CKP, VEGF and MVD.</p><p><b>RESULTS</b>The enhancement on spiral CT images increased with the levels of VEGF expression and MVD counting (P<0.01). Significant correlations were observed between VEGF expression, MVD counting and such spiral CT findings as lobular contours, cusp-like or sawtooth-like margins and tumor invasions of the pleural membrane, pericardium and great vessels (P<0.05). CKP expression showed no obvious correlation to these findings by spiral CT.</p><p><b>CONCLUSION</b>Spiral CT can reflect the pathological characteristics of thymoma, and may serve as a noninvasive modality for preoperative evaluation of thymoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Timoma
/
Neoplasias do Timo
/
Diagnóstico por Imagem
/
Tomografia Computadorizada Espiral
/
Fator A de Crescimento do Endotélio Vascular
/
Microvasos
/
Genética
/
Queratinas
/
Metabolismo
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS