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Effect of sinomenine on tumor necrosis factor-alpha and nuclear factor-kappaB in the heterotopic tissue in rats with endometriosis / 南方医科大学学报
Journal of Southern Medical University ; (12): 1874-1876, 2010.
Artigo em Chinês | WPRIM | ID: wpr-330817
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of sinomenine on the level of tumor necrosis factor-alpha (TNF-alpha) and nuclear factor-kappaB (NF-kappaB) and in the heterotopic tissue in rats with endometriosis.</p><p><b>METHODS</b>The rats with endometriosis were divided into sinomenine lavage group, blank control group, model group and danazol group, and the levels of TNF-alpha and NF-kappaB in the heterotopic tissues of the rats were detected with immunohistochemistry.</p><p><b>RESULTS</b>Sinomenine lavage and danazol treatment both significantly decreased the levels of levels of TNF-alpha and NF-kappaB in the heterotopic tissues of the rats as compared with the model group (P<0.05), and lesions were significantly smaller in sinomenine lavage group than in danazol group.</p><p><b>CONCLUSION</b>Sinomenine can inhibit the production and activity of TNF-alpha and NF-kappaB to suppress the adhesion, implantation, infiltration and growth of the endometrial cells in the rat model of endometriosis.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Coristoma / NF-kappa B / Fator de Necrose Tumoral alfa / Ratos Wistar / Danazol / Endometriose / Metabolismo / Morfinanos Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Coristoma / NF-kappa B / Fator de Necrose Tumoral alfa / Ratos Wistar / Danazol / Endometriose / Metabolismo / Morfinanos Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2010 Tipo de documento: Artigo