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Correlation between the expression of Fas, Bcl-2 in peripheral blood lymphocytes and the level of IFN-gamma, IL-4 in serum of patients with condyloma acuminata / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 90-91, 2004.
Artigo em Inglês | WPRIM | ID: wpr-330863
ABSTRACT
In order to investigate the correlation between the expression of the apoptotic regulatory proteins (Fas, Bcl-2) in peripheral blood lymphocytes (PBLC) and the level of IFN-gamma and IL-4 in serum of the patients with condyloma acuminata (CA) in the immune pathogenesis of CA, indirect immunofluorescence labeling method of flow cytometer and solid sandwich ELISA method were performed for detecting the expression of Fas, Bcl-2 in PBLC and the level of IFN-gamma and IL-4 in serum of 60 cases of CA. The results showed the expression level of Fas in PBLC of CA was significantly higher than in the normal control group, but the expression level of Bcl-2 was significantly lower (both P<0.01). The level of IFN-gamma in serum of CA was significantly lower than in the normal control group (P<0.01), but IL-4 was significantly lower (both P<0.01). The expression of Fas in PBLC had a negative correlation with the level of IFN-gamma in serum of patients with CA, but had a positive correlation with the level of IL-4; The expression of Bcl-2 had a positive correlation with the level of IFN-gamma, but had a negative correlation with the level of IL-4. All the correlation coefficients had significant difference by t test (P<0.01). It was suggested abnormal apoptosis in PBLC, the suppressed secretion of the TH1-associated cytokines (eg IFN-gamma) and the increased secretion of the TH2-associated cytokines (eg IL-4) existed in the patients with CA and might play an important role in the immune pathogenesis of CA.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sangue / Linfócitos / Condiloma Acuminado / Interleucina-4 / Interferon gama / Apoptose / Receptor fas / Proteínas Proto-Oncogênicas c-bcl-2 / Citometria de Fluxo / Metabolismo Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sangue / Linfócitos / Condiloma Acuminado / Interleucina-4 / Interferon gama / Apoptose / Receptor fas / Proteínas Proto-Oncogênicas c-bcl-2 / Citometria de Fluxo / Metabolismo Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Ano de publicação: 2004 Tipo de documento: Artigo