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Experimental study of vascular endothelial growth factor gene therapy for avascular necrosis of the femoral head / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 297-316, 2003.
Artigo em Inglês | WPRIM | ID: wpr-330924
ABSTRACT
To explore a new method for the therapy of the avascular necrosis of the femoral head, the recombinant plasmid pCD-hVEGF165 was mixed with collagen and was implanted in the necrotic femoral head. The expression of vascular endothelial growth factor (VEGF) was detected by RNA dot hybridization and immunohistochemical method. The repair of the femoral head was observed by histological method. The results showed that the expression of VEGF was detectable in the femoral head treated with VEGF gene. Angiogenesis in these femoral heads was more abundant than the control. Bone repairing was augmented in the femoral head treated with VEGF gene. The results suggest that angiogenesis in bone tissue could be augmented by gene transfection of VEGF and bone repairing would be accelerated accordingly.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteogênese / Plasmídeos / Terapêutica / Proteínas Recombinantes / Terapia Genética / Distribuição Aleatória / Colágeno / Técnicas de Transferência de Genes / Neovascularização Fisiológica / Implantes Experimentais Limite: Animais Idioma: Inglês Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteogênese / Plasmídeos / Terapêutica / Proteínas Recombinantes / Terapia Genética / Distribuição Aleatória / Colágeno / Técnicas de Transferência de Genes / Neovascularização Fisiológica / Implantes Experimentais Limite: Animais Idioma: Inglês Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Ano de publicação: 2003 Tipo de documento: Artigo