Research advances of genomic GYP coding MNS blood group antigens / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 200-204, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-330990
ABSTRACT
The MNS blood group system includes more than 40 antigens, and the M, N, S and s antigens are the most significant ones in the system. The antigenic determinants of M and N antigens lie on the top of GPA on the surface of red blood cells, while the antigenic determinants of S and s antigens lie on the top of GPB on the surface of red blood cells. The GYPA gene coding GPA and the GYPB gene coding GPB locate at the longarm of chromosome 4 and display 95% homologus sequence, meanwhile both genes locate closely to GYPE gene that did not express product. These three genes formed "GYPA-GYPB-GYPE" structure called GYP genome. This review focuses on the molecular basis of genomic GYP and the variety of GYP genome in the expression of diversity MNS blood group antigens. The molecular basis of Miltenberger hybrid glycophorin polymorphism is specifically expounded.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antígenos de Grupos Sanguíneos
/
Cromossomos Humanos Par 4
/
Dados de Sequência Molecular
/
Homologia de Sequência
/
Alergia e Imunologia
/
Genética
/
Sistema do Grupo Sanguíneo MNSs
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2012
Tipo de documento:
Artigo
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