Prognostic factors and treatment of 74 patients with dermatofibro-sarcoma protuberans / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 122-125, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-331212
ABSTRACT
<p><b>OBJECTIVE</b>To analyze treatment and prognostic factors of 74 patients with dermatofibro-sarcoma protuberans (DFSP).</p><p><b>METHODS</b>From August 1990 to November 1999, 74 patients with DFSP confirmed pathologically were treated. There were 52 males and 22 females with a median age of 37 years (range 4 to 80 years) on diagnosis. Seventeen patients were treated by extensive excision and 2 by limited excision. Fifty-two patients had surgical resection alone (S), and 22 postoperative radiotherapy (S + R) of 50-70 Gy. The multivariate parameters were analyzed using Cox model. Kaplan-Meier and Log-Rank test were used to evaluate the results of the recurrence-free survival.</p><p><b>RESULTS</b>The rate of recurrence was 28.4% for all patients. The 5-year recurrence-free survival rate (RFSR) was 66.6% and the 10-year RFSR was 52.5%. The 5-year and 10-year in the S group were 58.4% and 41.2%, compared with 90.0% and 83.3% in the S + R group (P < 0.05). The 5-year and 10-year RFSR in the pathologically positive margin group were 57.5% and 41.4% respectively, compared with the 75.0% and 56.6% in the pathologically negative group (P < 0.05). Multivariate analysis suggested radiotherapy and negative pathological margins were favorable prognostic factors.</p><p><b>CONCLUSION</b>Post-operation radiotherapy and pathological margin are the independent prognostic factors.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cuidados Pós-Operatórios
/
Prognóstico
/
Radioterapia
/
Neoplasias Cutâneas
/
Cirurgia Geral
/
Modelos de Riscos Proporcionais
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Estudos Retrospectivos
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Seguimentos
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Mortalidade
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Dermatofibrossarcoma
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Aged80
/
Criança
/
Criança, pré-escolar
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Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2005
Tipo de documento:
Artigo
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