Analysis of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 657-659, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-331238
ABSTRACT
<p><b>OBJECTIVE</b>To study the BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives.</p><p><b>METHODS</b>Genomic DNA from 41 patients' peripheral blood mononuclear cells was studied by using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) and DNA sequencing. BRCA1 mutations were detected in the whole gene sequence.</p><p><b>RESULTS</b>Disease-related BRCA1 mutations were detected in 3 of the 41 patients studied. Two of the 3 patients were younger than 35 years old, and one patient with family history.</p><p><b>CONCLUSION</b>The incidence of BRCA1 mutations in Chinese patients with early onset breast cancer is similar to that reported from western countries, but the incidence of mutations in Chinese breast cancer patients with affected relatives is comparatively low.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Neoplasias da Mama
/
DNA de Neoplasias
/
Análise Mutacional de DNA
/
Leucócitos Mononucleares
/
Química
/
China
/
Reação em Cadeia da Polimerase
/
Éxons
/
Idade de Início
Limite:
Adulto
/
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2004
Tipo de documento:
Artigo
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