Clinicopathologic significance of CD105 mRNA expression in human breast carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 38-40, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-331247
ABSTRACT
<p><b>OBJECTIVE</b>To study endoglin (CD105) gene expression in breast cancer and its clinicopathologic significance.</p><p><b>METHODS</b>In 40 patients with breast cancers, CD105 mRNA was detected at center and periphery of tumor and at nearby normal tissue by RT-PCR.</p><p><b>RESULTS</b>The difference in CD105 mRNA expressions between cancer and normal breast tissue was significant (t = 12.08, P < 0.05), and the expression was significantly higher at the tumor periphery than at the tumor center (t = 7.52, P < 0.05). CD105 over-expression was related to lymph node metastases (t = 2.71, P < 0.05), but not to age, tumor size, pathologic grade or pathologic type (P > 0.05).</p><p><b>CONCLUSION</b>CD105 over-expression may play a crucial role in the progression of breast cancer and lymph node metastasis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias da Mama
/
RNA Mensageiro
/
Biomarcadores Tumorais
/
Antígenos CD
/
Regulação Neoplásica da Expressão Gênica
/
Carcinoma Ductal de Mama
/
Receptores de Superfície Celular
/
Molécula 1 de Adesão de Célula Vascular
/
Endoglina
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2005
Tipo de documento:
Artigo
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