Replication of pathological scar in nude mice / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 126-129, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-331510
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the feasibility of reproduce hypertrophic scar and keloid in nude mice in the study of pathological scars.</p><p><b>METHODS</b>Pieces (0.8 x 0.8 x 0.5 cm) of hypertrophic scars and keloids were implanted into subcutaneous tissue of the nude mice for 16 days, during this period the gross condition of the nude mice and the state of the implants were observed. The implants were extracted after 16 days, and the volume, the microscopic characteristics of the scar, the content of acid mucopolysaccharide, and different types of collagen were determined and compared with that of the original specimens.</p><p><b>RESULTS</b>All mice survived with nice wound healing after the surgery. There was no obvious difference in the acid mucopolysaccharide content in keloid and hyperplastic scar before implantation (3448 +/- 1452, 1940 +/- 509), and after implantation (3237 +/- 1871, 1809 +/- 552, P > 0.05). The implants maintained the collagen pattern, with no signs of cell degeneration and necrosis.</p><p><b>CONCLUSION</b>This experiment showed that the viability and morphology of hypertrophic scars and keloids were maintained after they were implanted in nude mice. Therefore it is feasible to use nude mice as the animal model in the study of hypertrophic scars and keloids.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Cicatriz Hipertrófica
/
Modelos Animais de Doenças
/
Queloide
/
Camundongos Endogâmicos BALB C
/
Camundongos Nus
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Burns
Ano de publicação:
2007
Tipo de documento:
Artigo
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