Physiological and pathophysiological meanings of gastrointestinal smooth muscle motor unit SIP syncytium / 生理学报
Acta Physiologica Sinica
;
(6): 621-627, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-331624
ABSTRACT
Gastrointestinal smooth muscle layer contains two kinds of interstitial cells with special differentiation, i.e., interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor α-positive (PDGFRα) cells. The ICC and PDGFRαcells contact with smooth muscle cells (SMCs) by gap junctions and regulate contractive function of the SMCs. Therefore, these three kinds of cells constitute a functional syncytium, i.e., the SMC, ICC and PDGFRαcells syncytium (SIP syncytium). Various neurotransmitters, humoral factors, endogenous bioactive molecules, as well as drugs regulate gastrointestinal motility through the SIP syncytium. In this review, we introduce the concept of SIP syncytium and summarize functions of the syncytium, as well as its physiological and pathological significances.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células Gigantes
/
Receptor alfa de Fator de Crescimento Derivado de Plaquetas
/
Miócitos de Músculo Liso
/
Células Intersticiais de Cajal
/
Motilidade Gastrointestinal
/
Músculo Liso
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2016
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS