P2X7 receptor and inflammatory bowel disease / 生理学报
Acta Physiologica Sinica
;
(6): 343-351, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-331649
ABSTRACT
P2X7 receptors are closely associated with inflammation, and they have been found to be expressed on colonic cells broadly. In animal model of colonic inflammation, ATP/P2X7 signaling mainly promotes inflammation, and a variety of cells, including macrophages, dendritic cells, T cells, mast cells and enteric neurons are involved in this process. However, in the toxoplasmic ileitis, P2X7 signaling plays a role in inhibiting the inflammation. But, the underlying mechanisms are still not clear. This review outlined the research progresses of P2X7 receptors in inflammatory bowel disease (IBD) to provide some clues for the further studies on the relationship between P2X7 receptors and IBD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linfócitos T
/
Doenças Inflamatórias Intestinais
/
Transdução de Sinais
/
Modelos Animais de Doenças
/
Receptores Purinérgicos P2X7
/
Macrófagos
/
Mastócitos
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2016
Tipo de documento:
Artigo
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