Mechanism of cardiac atrophy under weightlessness/simulated weightlessness / 生理学报
Acta Physiologica Sinica
;
(6): 194-200, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-331666
ABSTRACT
Cardiac remodeling is the heart's response to external or internal stimuli. Weightlessness/simulated weightlessness leads to cardiac atrophy and heart function declining. Understanding the mechanism of cardiac atrophy under weightlessness is important to help astronaut recover from unloading-induced cardiovascular changes after spaceflight. Unloading-induced changes of hemodynamics, metabolic demands and neurohumoral regulation contribute to cardiac atrophy and function declining. During this process, Ca(2+)-related signaling, NF-κB signaling, ERK signaling, ubiquitin-proteasome pathway and autophagy are involved in weightlessness-induced cardiac atrophy. This article reviews the underlying mechanism of cardiac atrophy under weightlessness/simulated weightlessness.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Atrofia
/
Voo Espacial
/
Ausência de Peso
/
NF-kappa B
/
Simulação de Ausência de Peso
/
Coração
/
Cardiopatias
/
Hemodinâmica
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2016
Tipo de documento:
Artigo
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