Study on the molecular epidemiology of Mycobacterium tuberculosis in Shanghai / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 707-710, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-331800
ABSTRACT
<p><b>OBJECTIVE</b>To explore the molecular-epidemiology of Mycobacterium tuberculosis in Shanghai.</p><p><b>METHODS</b>Drug-resistant and drug-susceptible strains of M. tuberculosis were randomly selected from the bank of M. tuberculosis of Shanghai Municipal Center for Disease Control and Prevention and were genotyped by mycobacterial interspersed repetitive units(MIRU) and Spoligotyping methods. The genotyping results were analyzed and combined with epidemiological data.</p><p><b>RESULTS</b>The Spoligotyping results demonstrated that 89 % (81/91) of the strains belonged to the Beijing genotype. Of the patients who had received BCG-vaccination,88.5% (54/61) infected with strains of Beijing genotype and 90.0% (27/30) of the patients were not BCG-vaccinated. However, the difference was not statistically significant. Drug-resistant rate from those strains of Beijing genotype was 45.7 (37/81), lower than that of non-Beijing genotype (60.0% ,6/10). Again,the difference was not statistically significant. The MIRU results showed that 62.6 % (57/91) were strains of clusters.</p><p><b>CONCLUSION</b>The Beijing genotype of M. tuberculosis were found to be the dominant strains in Shanghai. The associations between Beijing genotype strains and BCG vaccination or drug-resistant were not found. Results from cluster analysis suggested that some cases might belong to the newly developed cases.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tuberculose
/
China
/
Epidemiologia
/
Vacinação
/
Sequências Repetitivas Dispersas
/
Farmacorresistência Bacteriana
/
Alergia e Imunologia
/
Genética
/
Genótipo
/
Mycobacterium bovis
Tipo de estudo:
Estudo de rastreamento
Limite:
Adolescente
/
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2005
Tipo de documento:
Artigo
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