Evaluation on the safety and immunogenicity of Canada split influenza virus vaccine / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 503-506, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-331848
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the safety and immunogenicity of Canada split influenza virus vaccine.</p><p><b>METHODS</b>Cluster samples were by randomly chosen and divided into split vaccination group and homoimported influenza vaccination group.</p><p><b>RESULTS</b>After injection, fever-reaction and local reaction rates of 'trial' group were found as 3.69% and 1.75% respectively, but no statistical significance was found when compared with 'control' group. However the antibody positive rates of 'trail' and 'control' groupsappeared statistically significant (H1N1 96.8% vs. 92.3%, H3N2 95.8% vs. 90.2%, B 52.3% vs. 62.3%). For geometric mean titer (GMT) of type H1N1, H3H2 and B antibody, 'trial' group and 'control' group increased 22.4, 16.8, 8.2 and 21.2, 12.5 and 7.4 times respectively. The antibody protective rates of type H1N1, H3N2 and B were 99%, 99% and 53.9% for 'trial' group, and 96.2%, 98.4% and 62.3% for 'control' but with no statistically significant difference.</p><p><b>CONCLUSION</b>Influenza split vaccine made in Shire company in Canada was safe and with good immunogenicity.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Orthomyxoviridae
/
Fatores de Tempo
/
Canadá
/
Vacinas Virais
/
Fatores Etários
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Alergia e Imunologia
/
Injeções
/
Formação de Anticorpos
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
País/Região como assunto:
América do Norte
Idioma:
Chinês
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2005
Tipo de documento:
Artigo
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