Effect of the disassembled recipes of dahuang zhechong pill on proliferation and apoptosis of vascular smooth muscle cells in atherosclerotic rabbits / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 913-917, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-331952
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of the disassembled recipes of Dahuang Zhechong Pill (DRDZP) on proliferation and apoptosis of vascular smooth muscle cell (VSMC) of thoracic aorta in atherosclerotic rabbits.</p><p><b>METHODS</b>The atherosclerotic rabbit model was induced by high-cholesterol diet and immune injury of endothelium. Expression of proliferating cell nuclear antigen (PCNA) in VSMC was detected by SP immunohistochemical technique, and VSMC apoptosis was observed with TUNEL technique.</p><p><b>RESULTS</b>Compared with the model control, PCNA expression in VSMC decreased, while apoptotic cells increased significantly in all the groups treated by DR-DZP (P < 0.01).</p><p><b>CONCLUSION</b>All the DR-DZP could inhibit VSMC proliferation and promote its apoptosis to modulate the balance between cell proliferation and apoptosis, so as to exert antiatherosclerotic action, among which the disassembled-recipe I is the main composition to contribute to antiatherosclerotic action of Dahuang Zhechong Pill.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aorta Torácica
/
Patologia
/
Farmacologia
/
Medicamentos de Ervas Chinesas
/
Imuno-Histoquímica
/
Células Cultivadas
/
Apoptose
/
Antígeno Nuclear de Célula em Proliferação
/
Marcação In Situ das Extremidades Cortadas
/
Miócitos de Músculo Liso
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2006
Tipo de documento:
Artigo
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