Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza A virus / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 97-99, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-332417
ABSTRACT
<p><b>OBJECTIVE</b>To construct adenovirus vector vaccine against H5N1 influenza virus and study on the immunogenicity.</p><p><b>METHODS</b>In this study, we amplified hemagglutinin (HA) gene sequence of H5N1 influenza virus (A/Anhui/1/2005), then constructed an adenovirus vector vaccine (Adv-HA), followed by tests in BALB/c mice for the immunogenicity with the vaccine and immunization strategies.</p><p><b>RESULTS</b>The recombinate Adv-HA vaccine could effectively induce both humoral and cellular immunity against human H5N1 influenza virus.</p><p><b>CONCLUSION</b>The Adv-HA vaccination against H5N1 influenza is a potential strategy and worthy of further investigation.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Virologia
/
Vacinas contra Influenza
/
Distribuição Aleatória
/
Linhagem Celular
/
Adenoviridae
/
Vacinação
/
Glicoproteínas de Hemaglutininação de Vírus da Influenza
/
Alergia e Imunologia
/
Influenza Humana
/
Virus da Influenza A Subtipo H5N1
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2009
Tipo de documento:
Artigo
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