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Teicoplanin Dosing Strategy for Treatment of Staphylococcus aureus in Korean Patients with Neutropenic Fever
Yonsei Medical Journal ; : 616-623, 2011.
Artigo em Inglês | WPRIM | ID: wpr-33258
ABSTRACT

PURPOSE:

The present study was conducted to determine and compare the target attainment rate (TAR) between microorganism-nonspecific (Ctrough) and microorganism-specific (AUC24/MIC) targets over two weeks of teicoplanin administration according to several dose regimens for the treatment of Staphylococcus aureus in Korean patients with neutropenic fever. MATERIALS AND

METHODS:

One thousand virtual concentrations were obtained for each dose using the population pharmacokinetic parameters of teicoplanin adopted from a published study. Simulation of 1,000 virtual MICs was performed using the MICs of 78 clinical isolates of S. aureus collected from a hospital in Korea. Thereafter, these simulated MICs were randomly allocated to 1,000 virtual patients in whom the TARs for AUC24/MIC >125 [or 345] and Ctrough >10 [or 20] mg/L were determined. The relationship of the maintenance dose with the steady-state TAR was predicted with respect to the AUC24/MIC >125 [or 345] using logistic analysis.

RESULTS:

The standard dose regimen of teicoplanin showed TARs of about 70% [or 33%] and 70% [or 20%] at steady-state in cases with AUC24/MIC >125 [or 345] and Ctrough >10 [or 20] mg/L, respectively.

CONCLUSION:

The current standard dose regimen was predicted to be insufficient to adequately treat S. aureus in Korean patients with neutropenic fever. To assure at least an 80% TAR in this population, dose adjustment of teicoplanin should be considered.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus / Simulação por Computador / Testes de Sensibilidade Microbiana / Resultado do Tratamento / Teicoplanina / Relação Dose-Resposta a Droga / República da Coreia / Febre / Antibacterianos Tipo de estudo: Estudo prognóstico Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus / Simulação por Computador / Testes de Sensibilidade Microbiana / Resultado do Tratamento / Teicoplanina / Relação Dose-Resposta a Droga / República da Coreia / Febre / Antibacterianos Tipo de estudo: Estudo prognóstico Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 2011 Tipo de documento: Artigo