Detection of gene expression pattern in the early stage after spinal cord injury by gene chip / 中华创伤杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To study the changes of the gene expression pattern of spinal cord tissues in the early stage after injury by DNA microarray (gene chip).</p><p><b>METHODS</b>The contusion model of rat spinal cord was established according to Allen's falling strike method and the gene expression patterns of normal and injured spinal cord tissues were studied by gene chip.</p><p><b>RESULTS</b>The expression of 45 genes was significantly changed in the early stage after spinal cord injury, in which 22 genes up-regulated and 23 genes down-regulated.</p><p><b>CONCLUSIONS</b>The expression of some genes changes significantly in the early stage after spinal cord injury, which indicates the complexity of secondary spinal cord injury.</p>