Functional recovery of the spinal cord following ischemia and reperfusion injury / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 186-189, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-332970
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes of excitatory amino acids (EAAs) and intracellular calcium ([Ca2+]i), and the protective effect of EAAs receptor antagonists in the tissues of rabbit lumbar spinal cord after 40-minues ischemia and 4-hours reperfusion.</p><p><b>METHODS</b>Thirty healthy rabbits were divided into six groups sham-operation, 40-minues ischemia, 4-hour reperfusion, ketamine and MgSO4 treatment, ketamine treatment, and saline treatment groups. The contents of EAAs (glutamate and aspartate) and [Ca2+]i were measured.</p><p><b>RESULTS</b>The contents of glutamate and aspartate were decreased to 15.18 micromol/g+/-2.33 micromol/g and 9.99 micromol/g+/-0.69 micromol/g, respectively; 13.75 micromol/g+/-2.58 micromol/g and 6.49 micromol/g+/-1.39 micromol/g after reperfusion. In the ischemia group, the [Ca2+]i was elevated to 221.2 microg/g+/-4.27 microg/g, and elevated further to 298.3 microg/g+/-9.26 microg/g after reperfusion, being significantly higher than that of ischemia and control groups. Ketamine could obviously increase the level of glutamate and aspartate and decrease the level of [Ca2+]i during the ischemia and reperfusion injury.</p><p><b>CONCLUSIONS</b>The excitotoxicity of EAAs and the overload of calcium induced by EAAs play a harmful role in ischemia and reperfusion injury. Ketamine has an effective inhibitory effect.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medula Espinal
/
Sangue
/
Traumatismo por Reperfusão
/
Distribuição Aleatória
/
Cálcio
/
Receptores de Aminoácido
/
Aminoácidos Excitatórios
/
Isquemia
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Journal of Traumatology
Ano de publicação:
2002
Tipo de documento:
Artigo
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