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Effect of CCR5delta32, CCR5m303, CCR2-64I and SDF1-3'A gene polymorphism on the prognosis of Chinese HIV-1 carriers / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 256-259, 2005.
Artigo em Chinês | WPRIM | ID: wpr-333028
ABSTRACT
<p><b>OBJECTIVE</b>To study how CCR5delta32, CCR5m303, CCR2-64I, SDF1-3'A gene polymorphisms affect the prognosis of Chinese HIV-1 carrier.</p><p><b>METHODS</b>Epidemiologic survey was done to the HIV-1 carriers who were found in Shenzhen area. PCR/RFLP technology was applied to analyze CCR5delta32, CCR5m303, CCR2-64I, SDF1-3'A gene polymorphisms of the HIV-1 carriers. The plasma virus load and CD4+ cell counting was assayed. The incubation period of some carriers was estimated. SPSS11.0 software was used to analyze the data.</p><p><b>RESULTS</b>No persons with CCR5delta32 and CCR5m303 mutation genotype were found from 189 HIV-1 carriers. SDF1-3'A allele frequency was 26.14% and CCR2-64I allele 19.82%. The carriers were divided into high virus load group (virus load < 20,000 copies/ml) and low virus load group (virus load > or =20,000 copies/ml). It was found by one-way ANOVA analysis on the logarithm of virus load that there was no significant difference between CCR2-64I wild genotype and cross bred genotype (P=0.272). One-way ANOVA analysis on delitescence of some carriers showed that there was not significant difference between CCR2-64I wild genotype and cross bred genotype (P=0.662). One-way ANOVA analysis on the logarithm of virus load showed that there was significant difference among SDF1-3'A wild genotype, cross bred genotype and pure mutation genotype (P=0.001).</p><p><b>CONCLUSION</b>CCR2-64I gene mutation may not significantly affect virus load of Chinese HIV-1 carriers, nor it affect the incubation period of HIV-1 carriers. SDF1-3'A gene mutation can decrease virus load, but it may not prolong the incubation period of HIV-1 carriers.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Polimorfismo Genético / Prognóstico / Virologia / Polimorfismo de Fragmento de Restrição / Portador Sadio / China / Reação em Cadeia da Polimerase / Síndrome da Imunodeficiência Adquirida / HIV-1 Tipo de estudo: Estudo prognóstico Limite: Humanos País/Região como assunto: Ásia Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Polimorfismo Genético / Prognóstico / Virologia / Polimorfismo de Fragmento de Restrição / Portador Sadio / China / Reação em Cadeia da Polimerase / Síndrome da Imunodeficiência Adquirida / HIV-1 Tipo de estudo: Estudo prognóstico Limite: Humanos País/Região como assunto: Ásia Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2005 Tipo de documento: Artigo