Differential clinical diagnostic parameters of acute hepatitis B and flare of chronic HBV infection / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate useful clinical diagnostic parameters for differentiating acute hepatitis B and flare of chronic HBV infection.</p><p><b>METHODS</b>Using PCR method to detect viral level in the patient's serum, HBV marker was detected by ELISA kit. Liver function was also detected.</p><p><b>RESULTS</b>The patient can be diagnosed as acute hepatitis B if a patient has one of the following parameters (1)HBV-DNA negative on admission. (2) When the patient's ALT was lower than 400 IU/L, HBV-DNA was negative or HBsAg became negative or HBeAg/HBeAb seroconverted.</p><p><b>CONCLUSION</b>The viral DNA level, HBV marker and ALT can help differentiate acute hepatitis B and flare of chronic HBV infection.</p>