Roles of calcitonin gene-related peptide family in pain and opioid tolerance / 生理学报
Acta Physiologica Sinica
;
(6): 347-354, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-333096
ABSTRACT
The calcitonin gene-related peptide (CGRP) family mainly includes CGRPα, CGRPβ, adrenomedullin, calcitonin and amylin. The members of CGRP family and their receptors are widely distributed in the central and peripheral nervous systems. Studies show that members of CGRP family such as CGRP and adrenomedullin play important roles in the transmission of nociceptive information. At spinal level, CGRP promotes the transmission of nociceptive information, spinal morphine tolerance, migraine, inflammatory pain and neuropathic pain. At superspinal level, CGRP suppresses the transmission of nociceptive information. Adrenomedullin is a pain-related neuropeptide which has recently been demonstrated. It facilitates the transmission of nociceptive information and is involved in the development and maintenance of opioid tolerance. The involvement of amylin and calcitonin in pain is not clear yet.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor
/
Farmacologia
/
Fisiologia
/
Peptídeo Relacionado com Gene de Calcitonina
/
Tolerância a Medicamentos
/
Adrenomedulina
/
Polipeptídeo Amiloide das Ilhotas Pancreáticas
/
Nociceptividade
/
Analgésicos Opioides
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2013
Tipo de documento:
Artigo
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