Relationship between tumor necrosis factor A-308 gene polymorphism and aggressive periodontitis / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 268-271, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-333346
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between tumor necrosis factor (TNF) A-308 gene polymorphism and aggressive periodontitis (AgP).</p><p><b>METHODS</b>Anti-coagulated peripheral blood samples were obtained from 64 AgP patients, and 78 healthy controls (H). Genomic DNA was extracted from each sample. The TNF A-308 gene polymorphism was detected by standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Data were analyzed by SAS statistical software.</p><p><b>RESULTS</b>There was no significant difference in distribution of TNF A-308 genotype between AgP patients and healthy controls. But the ORs for genotype GA and allele A were 22.2 and 16.1 respectively in non-smoking male AgP patients.</p><p><b>CONCLUSIONS</b>The TNF A-308 genotype GA and allele A may be associated with AgP susceptibility in Chinese males.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Periodontite Agressiva
/
Polimorfismo Genético
/
Fator de Necrose Tumoral alfa
/
Predisposição Genética para Doença
/
Alelos
/
Frequência do Gene
/
Genética
/
Genótipo
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Stomatology
Ano de publicação:
2007
Tipo de documento:
Artigo
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