Gene expression profile changes in oral verrucous carcinoma and oral squamous cell carcinoma / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To determine the difference in the gene expression between human oral verrucous carcinoma (OVC) and oral squamous cell carcinoma (OSCC).</p><p><b>METHODS</b>cDNA chip was used to detect the mRNA of cancer tissue from 4 OVC and 4 OSCC. After profile blotted and handled by bioinformation, the gene expression of these two kinds of lesions was examined.</p><p><b>RESULTS</b>Using the BioStarH-40 profile, 593 different expression of genes was found. The rate of different genes was 15.2%, of which the expression of 283 genes increased (59 genes significantly increased) and 310 genes decreased (98 genes significantly decreased) in OVC tissue than that in OSCC.</p><p><b>CONCLUSIONS</b>The gene expression of OVC and OSCC was different, which many contribute to the different biological behavior of these two kinds of lesions.</p>