Association of pleomorphic adenoma gene 1 polymorphism and benign parotid tumor in Chinese Han population in Hainan Province / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1360-1365, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-333623
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1 (PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province.</p><p><b>METHODS</b>Sixty-five patients with benign parotid tumor and 69 healthy volunteers (control) were examined for Rs6474051 polymorphisms of PLAG1 gene by PCR and sequencing.</p><p><b>RESULTS</b>Of the 65 patients with benign parotid tumor, the frequencies of CC, CT, and TT genotypes were 33 (50.8%), 25 (38.5%), and 7 (10.7%), as compared to those of 44 (63.8%), 24 (34.8%), and 1 (1.4%) in the control group (P=0.05). The allele frequency of C/T was 70%/30% in patients with benign parotid tumor, significantly different from that in the control group (80.6%/19.4%, P<0.05).</p><p><b>CONCLUSION</b>Rs6474051 polymorphism of PLAG1 gene may be associated with the benign parotid tumor in Chinese Han population in Hainan Province, and the T allele is probably one of susceptible genes.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Fatores de Transcrição
/
Neoplasias Parotídeas
/
Estudos de Casos e Controles
/
Reação em Cadeia da Polimerase
/
Proteínas de Ciclo Celular
/
Polimorfismo de Nucleotídeo Único
/
Proteínas Supressoras de Tumor
/
Povo Asiático
/
Alelos
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2015
Tipo de documento:
Artigo
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