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Serum marker screening during the second trimester for prenatal diagnosis and predicting pregnancy outcome / 南方医科大学学报
Journal of Southern Medical University ; (12): 1059-1072, 2015.
Artigo em Chinês | WPRIM | ID: wpr-333683
ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical value of screening the serum markers during the second trimester of pregnancy in preventing congenital birth defect and predicting the pregnancy outcome.</p><p><b>METHODS</b>Between November, 2011 and October, 2013, a total of 25 520 pregnant women (15-20+6 gestational weeks) underwent a screening test of triple serum markers including free beta-human chorionic gonadotrophin (free βhCG), alpha-fetoprotein (AFP), and unconjugated estriol (µE3) during the second semester of pregnancy. The women identified by the screening test as having high risks were referred to invasive prenatal diagnosis by amniocentesis, or to color Doppler ultrasound examination for suspected patent neural tube defect (NTD), and their pregnancy outcomes were followed up.</p><p><b>RESULTS</b>High-risk pregnancies were identified by the screening test in 4.91% (1254/25520) of the total cohort. Of the 818 patients receiving invasive prenatal diagnosis, the abnormal rate was 5.75% (47/818). The high-risk pregnancies identified by the screening test was associated with a significantly higher rate of abnormal outcomes compared with the low-risk pregnancies (1.91% vs 0.1%, P<0.01). Of the 210 high-risk cases of NTD, a definite diagnosis was established in 34 cases. We also found that pregnancies at an advanced age (>35 years) was associated with increased risks for trisomy 21 compared with those at younger ages (15% vs 1.65%P<0.01). The detection rate of abnormal karyotypes in pregnancies with an abnormal MoM value of a single marker was 3.17% (6/189).</p><p><b>CONCLUSION</b>Screening tests of serum markers during the second trimester of pregnancy can be helpful to identify fetal chromosomal and anatomical anomalies, predict unfavorable pregnancy outcomes, and prevent birth defects in pregnancies at an advanced age. The MoM value of a single marker in the second trimester can be indicative of potential chromosomal abnormalities.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Segundo Trimestre da Gravidez / Diagnóstico Pré-Natal / Sangue / Resultado da Gravidez / Biomarcadores / Alfa-Fetoproteínas / Aberrações Cromossômicas / Síndrome de Down / Gonadotropina Coriônica Humana Subunidade beta / Diagnóstico Tipo de estudo: Estudo diagnóstico / Estudo prognóstico / Estudo de rastreamento Limite: Feminino / Humanos / Gravidez Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Segundo Trimestre da Gravidez / Diagnóstico Pré-Natal / Sangue / Resultado da Gravidez / Biomarcadores / Alfa-Fetoproteínas / Aberrações Cromossômicas / Síndrome de Down / Gonadotropina Coriônica Humana Subunidade beta / Diagnóstico Tipo de estudo: Estudo diagnóstico / Estudo prognóstico / Estudo de rastreamento Limite: Feminino / Humanos / Gravidez Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2015 Tipo de documento: Artigo