Effect of high-frequency stimulation to subthalamic nucleus on STR neuronal firing rates in Parkinson disease rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 83-87, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-333709
ABSTRACT
<p><b>AIM</b>To observe the change of STR neuronal firing rates with high frequency stimulation of subthalamic nucleus in PD rats.</p><p><b>METHODS</b>A model of Parkinson's disease was induced by unilateral administration of 6-hydroxydopamine into right substantia nigra in rats. After the high-frequency stimulation to STN, the spontaneous firing rates of STR on normal and PD rats were recorded by using extracellular recordings.</p><p><b>RESULTS</b>Stimulation caused a direct excited effect of STR neurons in normal rats whereas a excited and inhibited effect in PD rats. The inhibited effect was correlated with the stimulation period (r = 0.94).</p><p><b>CONCLUSION</b>Stimulation to STN may inhibit the spontaneous firing rates of STR neurons in PD rats. These results also give some clues that high-frequency stimulation to STN may be a effective therapy to the clinical treatment of Parkinson's disease.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Fisiologia
/
Terapêutica
/
Potenciais de Ação
/
Terapia por Estimulação Elétrica
/
Ratos Sprague-Dawley
/
Corpo Estriado
/
Núcleo Subtalâmico
/
Modelos Animais de Doenças
/
Neurônios
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2004
Tipo de documento:
Artigo
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