Effect of aspirin on pulmonary hypertension in rat during chronic hypoxia and hypercapnia / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 319-322, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-333764
ABSTRACT
<p><b>AIM</b>To study the effect of aspirin on chronic hypoxia and hypercapnic pulmonary hypertension.</p><p><b>METHODS</b>SD rats were randomly divided into normal control group (A), hypoxic hypercapnic group (B), hypoxic hypercapnia + aspirin group (C). The concentration of TXB2 and 6-keto-PGF1alpha in plasma and in lung were detected by the technique of radioimmunology.</p><p><b>RESULTS</b>(1) mPAP was significantly higher in B group than those of A and C group. Differences of mCAP were not significant in three groups. (2) Light microscopy showed that WA/TA (vessel wall area/total area) and PAMT (the thickness of medial smooth cell layer) were significantly higher in B group than those of A and C group. (3) The concentration of TXB2 and 6-keto-PGF1alpha in plasma and lung as well as the ratio of TXB2/6-keto-PGF1alpha were significantly higher in rats of B group than those of A and C group.</p><p><b>CONCLUSION</b>Aspirin may inhibit hypoxic hypercapnia pulmonary hypertension and pulmonary vessel remodeling.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Artéria Pulmonar
/
Tromboxano A2
/
6-Cetoprostaglandina F1 alfa
/
Artérias Carótidas
/
Aspirina
/
Epoprostenol
/
Ratos Sprague-Dawley
/
Hipercapnia
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2003
Tipo de documento:
Artigo
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