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Quantitative analysis of Tiam1 expression in lung cancer and its clinical significance / 南方医科大学学报
Journal of Southern Medical University ; (12): 1774-1777, 2011.
Artigo em Chinês | WPRIM | ID: wpr-333815
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the expression of T lymphoma invasion and metastasis inducing factor 1 (Tiam1) and the progression, metastasis, TNM stage, and histological types of lung carcinoma.</p><p><b>METHODS</b>Immunohistochemistry was performed to detect the expression of Tiam1 in 116 lung carcinoma specimens. The expression intensity (measured in positive unit, PU) of Tiam1 in these tissues was assessed quantitatively using Imagepro Plus image analysis software.</p><p><b>RESULTS</b>The PU of Tiam1 was significantly greater in primary lung carcinomas with lymph node metastases than in those without metastases (t=-2.089, P=0.039). Lung cancers of TNM stage II-IV had stronger expression than those of stage I (t=-2.272, P=0.025). The PU of Tiam1 differed significantly between different histological types of lung cancer, and squamouscell cell carcinoma had a lower PU than adenocarcinoma, large cell carcinoma and small cell carcinoma (P<0.05). The intensity of Tiam1 expression was not associated with the patients' gender, age, general types, smoking history, pneumoconiosis or differentiation of lung carcinoma.</p><p><b>CONCLUSION</b>These results strongly suggest that Tiam1 is an invasion and metastasis inducing factor of lung carcinoma. The overexpression of Tiam1 is closely associated with lymph node metastases, TNM stage and histological types of lung carcinoma.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Imuno-Histoquímica / Carcinoma de Células Escamosas / Adenocarcinoma / Fatores de Troca do Nucleotídeo Guanina / Proteína 1 Indutora de Invasão e Metástase de Linfoma de Células T / Neoplasias Pulmonares / Metástase Linfática / Metabolismo / Estadiamento de Neoplasias Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Imuno-Histoquímica / Carcinoma de Células Escamosas / Adenocarcinoma / Fatores de Troca do Nucleotídeo Guanina / Proteína 1 Indutora de Invasão e Metástase de Linfoma de Células T / Neoplasias Pulmonares / Metástase Linfática / Metabolismo / Estadiamento de Neoplasias Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2011 Tipo de documento: Artigo