Effects of eight environmental endocrine disruptors on insulin resistance in patients with polycystic ovary syndrome: a preliminary investigation / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1753-1756, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-333821
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between 8 endocrine-disrupting chemicals in the serum and insulin resistance in patients with polycystic ovary syndrome (PCOS).</p><p><b>METHODS</b>This study was conducted among 60 patients with PCOS, including 23 with insulin resistance (PCOS-IR) and 37 without insulin resistance (PCOS-NIR), and 29 non-PCOS women seeking medical attention for infertility or menstrual disorder (control group). The serum levels of 6 phthalic acid esters (PEAs), bisphenol A (BPA) and octylphenol (OP) were measured in all the subjects.</p><p><b>RESULTS</b>The levels of PAEs, BPA and OP showed no significant differences between PCOS patients and the control group (P>0.05). The serum level of OP was significantly lower in patients PCOS-IR than in those with PCOS-NIR (47.89 ng/ml vs 60.24 ng/ml, P<0.05).</p><p><b>CONCLUSION</b>PEAs and BPA do not produce obvious effect on the pathogenesis of PCOS or contribute to insulin resistance, but OP may play a role in insulin resistance in PCOS patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenóis
/
Ácidos Ftálicos
/
Síndrome do Ovário Policístico
/
Compostos Benzidrílicos
/
Sangue
/
Resistência à Insulina
/
Estudos de Casos e Controles
/
Poluentes Ambientais
/
Disruptores Endócrinos
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2011
Tipo de documento:
Artigo
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