Correlation of cardiac troponin T gene mutations to hypertrophic cardiomyopathy in Chinese patients / 南方医科大学学报
Journal of Southern Medical University
; (12): 1589-1591, 2011.
Article
em Zh
| WPRIM
| ID: wpr-333856
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study cardiac troponin T (TNNT2) gene mutations in Chinese patients with hypertrophic cardiomyopathy (HCM) and analyze the correlation between the genotype and phenotype.</p><p><b>METHODS</b>Ninety-five unrelated Chinese patients with HCM and 120 control individuals were screened for TNNT2 gene mutations. Seven exons (8, 9, 10, 11, 14, 15, and 16) in the functional regions of TNNT2 gene were amplified using PCR and the products were sequenced. The patients with positive results underwent further family screening.</p><p><b>RESULTS AND CONCLUSION</b>This study did not find any HCM-caused mutations in TNNT2 gene, a result different from the reported rates of TNNT2 gene mutation ranging from 10% to 20% in other nations, suggesting that TNNT2 gene is not a susceptible gene for HCM in Chinese population.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Cardiomiopatia Hipertrófica
/
Estudos de Casos e Controles
/
Troponina T
/
Povo Asiático
/
Genética
/
Mutação
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2011
Tipo de documento:
Article