Effect of the Dysbindin Gene on Antimanic Agents in Patients with Bipolar I Disorder
Psychiatry Investigation
; : 102-105, 2008.
Article
em En
| WPRIM
| ID: wpr-33386
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment. METHODS: A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (+/-19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T, rs2005976 G/A, rs760761 C/T and rs2619522 A/C). RESULTS: There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors. CONCLUSION: Although the small number of subjects is an important limitation in our study, DTNBP1 does not seem to be involved in acute antimanic efficacy.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Farmacogenética
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Transtorno Bipolar
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Ácido Valproico
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Antimaníacos
Limite:
Humans
Idioma:
En
Revista:
Psychiatry Investigation
Ano de publicação:
2008
Tipo de documento:
Article