Expression of deleted in liver cancer 1 and phosphorelated focal adhesion kinase in breast cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1448-1451, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-333889
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the expression of deleted in liver cancer 1 (DLC1) and phosphorelated focal adhesion kinase (p-FAK) in breast cancer tissue to further understand the molecular mechanisms of the carcinogenesis and metastasis of breast cancer.</p><p><b>METHODS</b>Immunohistochemistry was employed to determine the protein level of DLC1 and p-FAK in 61 breast cancer, 30 benign breast disease and the adjacent normal breast tissues.</p><p><b>RESULTS</b>The positivity rates of DLC1 differed significantly between breast cancer, benign and normal tissues (34.43%, 80.00% and 76.67%, respectively, P<0.001). The positivity rates of p-FAK in the 3 tissues were 77.05%, 33.33% and 26.67%, also showing significant differences (P<0.001). The aberrant expression of DLC1 showed an inverse correlation to p-FAK (κ=-0.4591). Both DLC1 and p-FAK were closely correlated to the carcinogenesis, clinical stage, PR and lymphatic metastasis of breast cancer (P<0.05), but not to the patients age, pathological subtype, familial history, ER or CerbB-2 (P>0.05).</p><p><b>CONCLUSION</b>The abnormal expression of DLC1 and p-FAK might participate in the carcinogenesis, progression, and metastasis of breast cancer. The role of DLC1 and p-FAK might be related to the regulation of progestone. DLC1 and p-FAK may serve as candidate markers for early diagnosis, prognostic evaluation and target treatment of breast cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fosforilação
/
Prognóstico
/
Neoplasias da Mama
/
Receptores de Progesterona
/
Carcinoma Ductal de Mama
/
Proteínas Ativadoras de GTPase
/
Proteínas Supressoras de Tumor
/
Quinase 1 de Adesão Focal
/
Metástase Linfática
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2011
Tipo de documento:
Artigo
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