Advance of research on relationship between ABCG2 and drug resistance in hematologic malignancies - review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 513-518, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-334079
ABSTRACT
ABCG2, a half-transporter concerning with the endo and exon-toxin-efflux, plays an important role in protecting the normal tissues from the toxin-hurt as well as mediating the multidrug resistance, because many of the chemotherapeutic drugs are the substrate of ABCG2. In this paper, the advance of research about this gene's single nucleotide polymorphisms (SNPs) was explained concisely. The relationship among ABCG2, the stem cells and the tyrosine kinase inhibitor (TKI) was reviewed. The research about drug resistance related-progress in hematologic malignancies was analyzed retrospectively and the present problems and the perspective in the future were discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Resistência a Múltiplos Medicamentos
/
Transportadores de Cassetes de Ligação de ATP
/
Resistencia a Medicamentos Antineoplásicos
/
Polimorfismo de Nucleotídeo Único
/
Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP
/
Genética
/
Proteínas de Neoplasias
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2009
Tipo de documento:
Artigo
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