Identification of a novel HLA allele DRB1*1462 by sequence-based typing / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 493-495, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-334084
ABSTRACT
This study was to identify a novel HLA-DRB1 allele in Chinese population by nucleotide sequence ana- lysis. The HLA typing of genes was performed by PCR-SSO and PCR-SSP, the ambiguous novel allele was identified by DNA sequence analysis. The results showed that the sequence of this new allele differed from DRB1*140101 by one nucleotide substitution at position 256 in exon 2 (G- > A), resulting in an amino acid change from Ala to Thr at codon 57. In conclusion, this allele is a novel one, which has been officially given the name DRB1*1462 by the WHO nomenclature committee in January 2006.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Teste de Histocompatibilidade
/
Dados de Sequência Molecular
/
Antígenos HLA-DR
/
Análise de Sequência de DNA
/
Povo Asiático
/
Alelos
/
Cadeias HLA-DRB1
/
Genética
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2009
Tipo de documento:
Artigo
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