Bone marrow mesenchymal stem cells: progress in bone/cartilage defect repair / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 135-139, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-334348
ABSTRACT
Mesenchymal stem cells (MSC) are thought to be multi-potent cells that have the potential to differentiate into lineages of mesenchymal tissues, including bone, cartilage, tendon, fat, muscle, and marrow stroma during embryo morphogenesis. In recent years, cells that have the characteristics of mesenchymal stem cells were isolated from marrow aspirates of human and a few animals. It was found that these cells retain the characteristics of stem cells in vitro and could be induced to differentiate exclusively into the osteocytic, chondrocytic, myoblastic and adipocytic lineages. It was demonstrated that MSC could heal clinically significant bone and cartilage defects in animal models. The role of MSC in repairing tendon defect was also testified. In addition, for its multi-potential to differentiate into lineages of mesenchymal tissues, MSC could be used as gene vehicle for gene therapy of trauma care.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Células-Tronco
/
Cirurgia Geral
/
Ferimentos e Lesões
/
Osso e Ossos
/
Células da Medula Óssea
/
Cartilagem
/
Diferenciação Celular
/
Células Cultivadas
/
Transplante de Medula Óssea
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2002
Tipo de documento:
Artigo
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