The regulation effect of interleukin-1 on expression of cartilage specificity gene Sox9 mRNA in the human intervertebral discs / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1704-1707, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-334425
ABSTRACT
<p><b>OBJECTIVE</b>To assess the regulating effects of interleukin-1 (IL-1) on gene expression of cartilage specificity gene Sox9 and type II collagen mRNA in the human intervertebral discs.</p><p><b>METHODS</b>RT-PCR were used to investigate the effects of IL-1 on gene expression of Sox9 and type II collagen mRNA in intervertebral discs cells cultures of embryo.</p><p><b>RESULTS</b>The Sox9 and type II collagen mRNA in intervertebral discs were decreased progressively along with the addition concentrations of IL-1 than the controls. And the mRNA of Sox9 and type II collagen also markedly decreased with the time of culture.</p><p><b>CONCLUSIONS</b>IL-1 could cause dose-dependent and time-dependent inhibition effects on Sox9 and type II collagen gene expression in human intervertebral discs.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fatores de Tempo
/
Fatores de Transcrição
/
RNA Mensageiro
/
Proteínas de Grupo de Alta Mobilidade
/
Expressão Gênica
/
Células Cultivadas
/
Interleucina-1
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Biologia Celular
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2006
Tipo de documento:
Artigo
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