Surveillance for occult HBV infection and HBsAg variants in blood donors / 病毒学报
Chinese Journal of Virology
;
(6): 178-184, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-334754
ABSTRACT
Occult hepatitis B virus (HBV) infection status of blood donors in a southern city in China was investigated by immunological assays and nucleic acid testing. Overall, 17 (0.19%, 95% CI 0.11%-0.30%) of the 9023 HBsAg negative samples were found to be positive for the presence of HBV DNA. "A" epitope sequences were obtained from 14 among them. Mutation(s) in aa124-aa147 existed in 6 (42.9%, 6/14) samples and 4 (66.7%, 4/6)were G145R mutation. Ratio of genotype C in occult donors (10/17) was statistically higher than HBs-positive donors (0/15, P<0.01), which implied that HBV genotype C leaded to occult infection more easily.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Virologia
/
Doadores de Sangue
/
Testes Imunológicos
/
DNA Viral
/
China
/
Vírus da Hepatite B
/
Epidemiologia
/
Alinhamento de Sequência
/
Classificação
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Virology
Ano de publicação:
2009
Tipo de documento:
Artigo
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