Study on the correlation of human influenza A/H3N2 hemagglutinin gene variation and the epidemic from 1995 to 2005 in China / 病毒学报
Chinese Journal of Virology
;
(6): 339-344, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-334886
ABSTRACT
To study the correlation of human influenza A/H3N2 hemagglutinin gene variation and the epidemic from 1995 to 2005 in China, 550 HA1 sequences of H3N2 viruses isolated in China were analyzed with phylogenetic tree. The results showed that the evolution of HA1 represented a long trunk with short side branches. The animo acid changes of HA1 mostly located at the antigenic sites or aside of them, but also may occur at the other sites simultaneously. The analysis also showed three possibilities of HA1 variation to cause H3N2 epidemic, the first is multiple site mutations happened simultaneously; the second is mutation sites happened gradually and then accumulated to multiple sites; the third is a single antigenic site mutation occurred simultaneously with the receptor binding site variation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Tempo
/
Variação Genética
/
China
/
Epidemiologia
/
Surtos de Doenças
/
Glicoproteínas de Hemaglutininação de Vírus da Influenza
/
Influenza Humana
/
Vírus da Influenza A Subtipo H3N2
/
Genes Virais
/
Genética
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Virology
Ano de publicação:
2007
Tipo de documento:
Artigo
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