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Bevacizumab (Avastin) inhibits lung cancer-induced pulmonary microvascular angiogenesis / 南方医科大学学报
Journal of Southern Medical University ; (12): 1027-1043, 2006.
Artigo em Chinês | WPRIM | ID: wpr-335001
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of bevacizumab (Avastin) on pulmonary microvascular angiogenesis induced by lung cancer.</p><p><b>METHODS</b>The effects of Avastin on cell growth, cell cycle and apoptosis of lung microvascular endothelial cells were assayed by flow cytometry.</p><p><b>RESULTS</b>Avastin inhibited the growth of lung microvascular endothelial cells and induced increase of cell apoptosis index in a concentration-dependent manner. With the increment of Avastin concentration from 25 to 100 microg/ml, avascular area increased from 0.944-/+0.073 cm square to 5.189-/+0.192 cm square, and the cell apoptosis index increased from 32.5%-/+1.5% to 39.25-/+1.6%.</p><p><b>CONCLUSION</b>Avastin can inhibit the growth and induce apoptosis of lung microvascular endothelial cells in three-dimensional culture, possibly in association with cell cycle arrest in G(0/1) phase.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Farmacologia / Capilares / Adenocarcinoma / Ciclo Celular / Células Cultivadas / Apoptose / Inibidores da Angiogênese / Linhagem Celular Tumoral / Células Endoteliais Limite: Animais / Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Farmacologia / Capilares / Adenocarcinoma / Ciclo Celular / Células Cultivadas / Apoptose / Inibidores da Angiogênese / Linhagem Celular Tumoral / Células Endoteliais Limite: Animais / Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2006 Tipo de documento: Artigo