Recombinant human endostatin induces apoptosis of human umbilical venous endothelial cells / 南方医科大学学报
Journal of Southern Medical University
;
(12): 978-980, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-335015
ABSTRACT
To investigate the effects of human endostatin on proliferation of human umbilical venous endothelial cells, the apoptosis of the endothelial cells treated with recombinant human endostatin was examined by fluorescence method and the cell proliferation activity analyzed by MTT assay. The results showed that human endostatin inhibited the proliferation of the endothelial cells with ED(50) of 550 ng/ml, and the inhibitory effect was enhanced with the increase of endostatin concentration, suggesting a dose-dependent inhibitory effect of human endostatin on endothelial cell proliferation. The mechanism of antiangiogenesis induced by human endostatin is related to the inhibition of cell proliferation and induction of apoptosis of the endothelial cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Veias Umbilicais
/
Proteínas Recombinantes
/
Linhagem Celular
/
Sobrevivência Celular
/
Apoptose
/
Inibidores da Angiogênese
/
Biologia Celular
/
Células Endoteliais
/
Endostatinas
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2006
Tipo de documento:
Artigo
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