Expression of hypoxia inducible factor-1α and insulin in pancreatic cancer and their correlation / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 348-351, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-335282
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation between the expressions of hypoxia inducible factor-1α (HIF-1α) and insulin in pancreatic cancer.</p><p><b>METHODS</b>HIF-1α and insulin expression was detected by immunohistochemistry in the center and the edge of pancreatic adenocarcinoma specimens of 65 cases. Western blot was used to detect HIF-1α expression and insulin level in the center and the edge of pancreatic adenocarcinoma specimens of 28 cases. The relationship between HIF-1α expression and insulin level in the pancreatic cancer was analyzed.</p><p><b>RESULTS</b>The results of immunohistochemistry and Western blot showed that HIF-1α protein expression was high in both the center and the edge of pancreatic cancers (P > 0.05), and insulin level was significantly higher at the edge of specimen than that in the center (P < 0.05). HIF-1α protein and insulin levels were positively correlated at the edge of cancer tissue (r = 0.374, P < 0.05), but no significant correlation between them in the center of cancerous tissue (r = -0.145, P > 0.05).</p><p><b>CONCLUSION</b>Insulin may promote the local invasion and metastasis of pancreatic cancer by up-regulating HIF-1α.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Pancreáticas
/
Patologia
/
Imuno-Histoquímica
/
Adenocarcinoma
/
Western Blotting
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
/
Insulina
/
Metabolismo
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2012
Tipo de documento:
Artigo
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