Expressions of cardiac sympathetic norepinephrine transporter and beta1-adrenergic receptor decreased in aged rats / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 203-210, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-335380
ABSTRACT
Evidence suggests that the deterioration of communication between the sympathetic nervous system and cardiovascular system always accompanies the aging of human and animals. Cardiac sympathetic norepinephrine (NE) transporter (NET) on presynaptic membrane is a predominant component to eliminate released NE in the synaptic cleft and maintains the sensitivity of the beta-adrenergic receptor (beta-AR). In the present study, we investigated NET and beta1-AR mRNA levels and sympathetic nerve density in cardiac sympathetic ganglion and left ventricular myocardium in 2- and 16-month-old rats with Northern blot analysis and immunohistochemistry. The expression levels of NET mRNA, NET protein and beta1-AR mRNA in the ganglia or myocardia of 16-month-old rats were markedly reduced by 67%, 26%, and 43%, respectively, in comparison with those in 2-month-old rats. Our results also show that aging induces a strong decrease of the catecholaminergic nerve fiber density.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Envelhecimento
/
RNA Mensageiro
/
Regulação da Expressão Gênica
/
Ratos Sprague-Dawley
/
Receptores Adrenérgicos beta 1
/
Proteínas da Membrana Plasmática de Transporte de Norepinefrina
/
Genética
/
Metabolismo
/
Miocárdio
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Zhejiang University. Science. B
Ano de publicação:
2009
Tipo de documento:
Artigo
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