Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1808-1814, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-335526
ABSTRACT
<p><b>BACKGROUND</b>Atherosclerosis is a complex vascular inflammatory disease. Aspirin is a mainstay in the prevention of vascular complications of atherosclerosis. In this study, the effectiveness of aspirin in suppressing atherosclerosis and the inflammation process was evaluated in rabbits fed with a high fat diet.</p><p><b>METHODS</b>Eighteen male New Zealand rabbits were randomly divided into 3 groups control group, untreated cholesterol-fed group, aspirin treated cholesterol-fed group, which were fed for 12 weeks. After 12 weeks, the aorta was harvested for pathologic morphology observation. Immunohistochemical analysis of cyclooxygenase-2 (COX-2), macrophage and vascular smooth muscle cell (VSMC) was performed. The statistical analysis was performed by the statistical program SPSS10.0.</p><p><b>RESULTS</b>The aorta plaque/intima size (P/I) by pathologic morphology observation was 0%, (59.6 +/- 13.7)% and (36.3 +/- 16.5)% in the control, untreated cholesterol-fed group and aspirin treated group, respectively. The maximum plaque thickness, the degree of artery stenosis and the proportion of the intimal circumference occupied by atheroma of the 3 groups were significantly different from each other (P < 0.01). The expression of COX-2 and macrophage in plaque of the aspirin treated group were decreased compared with that in untreated cholesterol-fed group. However, no difference was found in the expression of VSMC between the aspirin treated and the untreated cholesterol-fed group.</p><p><b>CONCLUSION</b>The mechanism of atherosclerosis suppression by aspirin in cholesterol-fed rabbits is related to the inhibition of COX-2 expression together with the reduced inflammation followed by, but not related to the hypolipidemic effects.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aorta
/
Patologia
/
Farmacologia
/
Sangue
/
Imuno-Histoquímica
/
Colesterol na Dieta
/
Aspirina
/
Aterosclerose
/
Ciclo-Oxigenase 2
/
Lipídeos
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2006
Tipo de documento:
Artigo
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